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Season
Season 1 Episode
- Season 1 Will Ferrell, Jenny McCarthy
- Season 1 Eva Mendes, "So You Think You Can Dance", Granny Basketball
- Season 1 Lisa Kudrow, 10 year-old Opera Singer, Adam Rodriguez
- Season 1 Carol Burnett, Rainn Wilson, Hollerin' Championships
- Season 1 Felicity Huffman, 'Animal Guys' Paul Hahn and David Riherd, Enrique Murciano
- Season 1 Julia Louis-Dreyfus, Illusionist Criss Angel, Mario Lopez
- Season 1 Debra Messing, Fashion Makeover with Lucky Magazine, Omar Epps
- Season 1 George Lopez, Jennifer Finnigan, Vacuum Cleaning Genius, Tim Bagley At A Cher Convention
- Season 1 Sela Ward, Chris Noth
- Season 1 Patricia Heaton, Duane Martin, Jesse McCartney
- Season 1 Jane Kaczmarek, Masi Oka, Champion Cloggers
- Season 1 Tom Bergeron, Eric Stromer, Elizabeth Perkins
- Season 1 Tim Daly, Domino Magazine
- Season 1 Connie Britton, Michael Clark Duncan
- Season 1 Jennifer Love Hewiitt, Jonny Lee Miller, J. Xavier
- Season 1 Virginia Madsen, Noah Gray-Cabey, Around The Office
- Season 1 Marcia Cross, Clinton Kelly, Isaiah Washington
- Season 1 Molly Ringwald, OK Go
- Season 1 Wanda Sykes, Goran Visnjic, Ruben Studdard
- Season 1 Peter Gallagher, Nathan Burton, Tyler James Williams
- Season 1 Bradley Whitford, Shelley Morrison, Eric Mabius, Mario Vazquez, Phil Pfister
- Season 1 Cheyenne Kimball, Laura Linney, Ricardo Antonio Chavira
- Season 1 Merv Griffin, Kim Raver, Author Jennifer Egan
- Season 1 Rob Morrow, Rebecca Cole, Anne Heche, Joshua Bell
- Season 1 Josh Duhamel, Alison Lohman, Authors Mark Leyner and Bill Goldberg, Aly & AJ Michalka
- Season 1 Kristin Chenoweth, Jill Conner Browne, Nick & Aaron Carter, the Sweet Potato Queens
- Season 1 Jamie Lee Curtis, The Mystic Pixies, Amy Smart, Taylor Swift
- Season 1 Lauren Holly, Ruben Studdard, Daniel Dae Kim
- Season 1 Cloris Leachman, Jensen Ackles, Dog Halloween Costumes with Teri Austin, ecostylist Danny Seo
- Season 1 James Denton, Yahoo 9's Maria Sansone, Angela Kinsey, JoJo
- Season 1 Steven Weber, Audra McDonald
- Season 1 Neil Patrick Harris, Kevin Federline
- Season 1 Jamie Kennedy, Jeffrey Sebelia, Meat Loaf, Card Thrower Rick Smith
- Season 1 Clay Aiken, Tysonia Tschinga "real life" Dancing with the Stars
- Season 1 Sean Hayes, Eddie Cibrian, Dog Whisperer Cesar Millan, Author Mitch Albom
- Season 1 Barry Manilow, Parminder Nagra, Tim Bagley visits "America's Got Talent", Kid's Ballroom Dancing
- Season 1 Mark Harmon, Hip Hop Champions, Constance Zimmer, Melora Hardin
- Season 1 Kevin Nealon, Antonio Sabato Jr.
- Season 1 Bob Saget, sex educator Sue Johanson
- Season 1 Molly Sims, Andrea Bowen, The Ten Tenors, Celebrity trainer Michael Carson
- Season 1 Cheryl Hines, Tim Gunn, Thanksgiving Dog Adoption Fashion Show
- Season 1 David Hyde Pierce, Linda Cardellini, Taylor Ware
- Season 1 Patricia Arquette, Champion Pirouette Dancer, Daily Candy Trends
- Season 1 Dax Shepard, Tom Arnold, Kimberley Locke
- Season 1 Reba McEntire, Patrick Wilson, RBD
- Season 1 Tom Bergeron, Trista and Ryan, Benji Schwimmer, Rupert Boneham
- Season 1 Sharon Stone, Scott Foley, Rusty Schwimmer, Paz Vega, Danny Seo
- Season 1 Wayne Brady, Penguins Pete and Penny, Nestle Toll House Bake Sale Finalist
- Season 1 Camryn Manheim, Phil Pfister, James Lesure, Author Karen Rizzo
- Season 1 Neil Patrick Harris, Josh Radnor, Alyson Hannigan, Jason Segel and Cobie Smulders
- Season 1 David Boreanaz, Julianne Nicholson, Bianca Ryan
- Season 1 Matthew Broderick, Donald Faison, Brian Baumgartner, the Bucket Boys, Catherine Lloyd Burns
- Season 1 Tracy Morgan, Melissa Peterman, Jarod Miller, Eric Stromer
- Season 1 Carrie Fisher, Paul Rodriguez, Nadine Velazquez
- Season 1 Rosanna Arquette, Tom Green, Adrian Pasdar
- Season 1 Marla Sokoloff, Taylor Hicks, "Campus Ladies"
- Season 1 Phyllis Diller
- Season 1 Carson Kressley, Beau Bridges, Amy Sedaris
- Season 1 Wendie Malick, Janice Dickinson
- Season 1 John Stamos, Brenda Strong, Cris Judd, Tyrese
- Season 1 David James Elliott, Michael Ealy, Lisa Edelstein, magician Nathan Burton
- Season 1 Jeffrey Tambor, Tisha Campbell, designer Mark Montano, Hall & Oates
- Season 1 Shawn and Marlon Wayans, Taylor Hicks
- Season 1 Oded Fehr, Rob Morrow, Rhea Perlman, Sarah Rush
- Season 1 Howie Mandel, Jennie Garth, Ahmet Zappa, psychic medium Lisa Williams
- Season 1 Jane Seymour, David Conrad, Ken Davitian, Joshua Radin
- Season 1 Alfre Woodard, Milo Ventimiglia, Fantasia Barrino
- Season 1 Billy Ray Cyrus, Richard Simmons, authors of "Party Confidential"
- Season 1 Hall & Oates, Brian McKnight, Clay Aiken, José Feliciano, Kimberley Locke, Celtic Woman
- Season 1 Emily Procter, Tichina Arnold, Goo Goo Dolls
- Season 1 Natalie Cole, Craig Bierko, Dave Annable, Blaine Zuckerman
- Season 1 Tom Bergeron, Tim Daly, Will Ferrell, Allison Janney, Davy Jones, Chris Noth, Jerry Springer
- Season 1 Patricia Heaton, Cheryl Hines, Debra Messing, Christine Taylor
- Season 1 Josh Duhamel, Jamie Kennedy, George Lopez, Mario Lopez
- Season 1 Selma Blair, Kristin Chenoweth, Lisa Kudrow, Laura Linney, Julia Louis-Dreyfus
- Season 1 Chandra Wilson, Jesse Bradford, Clay Aiken
The Megan Mullally Show
4.20 60 minutes The Megan Mullally Show is an American talk show hosted by Megan Mullally that debuted in syndication on September 18, 2006, and was cancelled in January 2007 due to its low ratings. Early promotions for the program featured Mullally as herself and as her Will & Grace character, Karen Walker. The talk show also aired nationally on TBS and was distributed by NBC Universal Television Distribution.
Promotional television advertisements featured Mullally standing in front of the title-card attempting to correct the voice-over announcer who throughout the commercial mispronounces her name as "Minnie Minnie Moo Moo" and "Monkey McMonkey" among other names.
The first episode featured actor Will Ferrell and Jenny McCarthy.
